is it factors like diet/ age, etc. or baroreceptors/ chemo receptors, just want to make sure i'm on the right line, thanks!What are the physiological factors that control blood pressure?
Three main factors determine blood pressure:
1) Heart - The heart can increase or decrease your body's blood pressure by changing its heart rate or contractility. Increases in heart rate and contractility leads to more blood pumped out of the heart, and thus increase your blood pressure. Beta blockers such as Toprol can be used to decrease the heart rate and contractility, lowering the blood pressure.
2) Kidneys - The kidneys control the amount of fluid and salt excretion and retention. Low perfusion of the renal arteries or low salt concentration in the blood can lead to the release of Renin, which activates a cascade that results in increased water and salt retention, thus increasing the blood pressure. This process is often targeted by many anti-hypertensive medications such as HCTZ and Aldactone diuretics, and ACE inhibitors.
3) Blood vessels - Arterioles can either constrict or dilate. Increasing the constriction of vessels leads to increased resistance in blood flow. This can lead to increases in blood pressure. Control of this process is through neural regulation such as sympathetic neuron firing, and angiotensin II hormonal regulation. This can be controlled by medications such as Ca channel blockers like nifedipine, ACE inhibitors, and in the case of an older male with BPH, alpha blockers such as prazosin.
Primary HTN can be caused by a variety of factors, many of which we don't really understand and are unable to identify. 60% of hypretensive patients have the condition because of excess salt in their diet, as their bodies are unable to handle salt well. The other 40% are a mystery, consisting of theories such as genetic mutations in proteins such as BMP-II, or enzymes that produce cortisol. These cases of HTN are usually well controlled by medication.
Secondary HTN, on the other hand, is rapid, severe, acute hypertension that is usually due to an underlying cause. Renal artery stenosis, either by atherosclerosis or familial diseases such as fibromuscular dysplasia can lead to excessive Renin release, leading to severe fluid retention. Certain malignancies such as Conn's Syndrome, Cushing's, Pheochromocytoma, and conditions such as Metabolic Syndrome associated with diabetes can all cause it. These cases of HTN are usually not controllable by the medications I mentioned above, and often times require surgery or intervention to resolve the underlying problem.
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